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Other serious side effects include problems breathing, light-headedness or fainting, blurred vision, confusion, nausea, and urinary retention. Food and Drug Administration has rated medications for safety during pregnancy on a scale of A through X for decades.The doctor should be notified immediately of any serious side effects. This rating is being gradually replaced with more detailed information, but the ranking is still helpful as a quick reference for many existing medications.If a patient has a deficiency or is completely lacking this enzyme an adequate analgesic effect will not be obtained.Estimates indicate that up to 7% of the caucasian population may have this deficiency. Smith Marsh, Pharm D, BC-ADM, CDE , Clinical Assistant Professor, Department of Pharmacy Practice; Clinical Pharmacist, College of Pharmacy, University of Illinois at Chicago; Mile Square Health Center, University of Illinois at Chicago Not surprisingly, adverse drug reactions are common.Most adverse drug reactions are relatively mild, and many disappear when the drug is stopped or the dose is changed.

A strong sedative effect of the older first generation antihistamines is one of the most distinguishing features between the two groups.

Doxepin is an antihistamine with additional antidepressant actions.

For the short term treatment of acute moderate pain which is not relieved by Paracetamol, ibuprofen or aspirin alone such as migraine attacks including the symptoms of migraine headache, nausea and vomiting.

Codeine is indicated in children older than 12 years of age for the treatment of acute moderate pain which is not considered to be relieved by other analgesics such as paracetamol or ibuprofen (alone).

Codeine should not be used in children below the age of 12 years because of the risk of opioid toxicity due to the variable and unpredictable metabolism of codeine to morphine (see sections 4.3 and 4.4).